KB-R7943 mesylate, CAS [[182004-65-5]]

Produktübersicht

• Artikelname: KB-R7943 mesylate, CAS [[182004-65-5]]
• Artikelnummer: FBM-10-1163
• Hersteller Artikelnummer: 10-1163
• Alternativnummer: FBM-10-1163-10MG,FBM-10-1163-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

TRPC channel blocker

Produkteigenschaften

• Molekulargewicht: 427.49
• Reinheit: 98% by TLC [ 10% methanol in methylene chloride + 0.1% NH4OH, Rf = 0.40] NMR (Conforms)
• Formulierung: Tan solid
• CAS Nummer: [182004-65-5]
• Formel: C16H17N3O3S CH3SO3H

Anwendungsbeschreibung

• Anwendungsbeschreibung: KB-R7943 is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX, IC50s = 1.2-2.4 µM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1, 0.7µM in cultured rat forebrain2). KB-R7943 has also been shown to inhibit the mitochondrial Ca2+ uniporter (MCU) - Ki = 5.5 µM.3 Recently shown to inhibit complex I in the mitochondrial respiratory chain (IC50 = 11.4 µM) and block NMDA receptors (IC50 = 13.4 µM).4