A-769662, CAS [[844499-71-4]]

Produktübersicht

• Artikelname: A-769662, CAS [[844499-71-4]]
• Artikelnummer: FBM-10-1171
• Hersteller Artikelnummer: 10-1171
• Alternativnummer: FBM-10-1171-5MG, FBM-10-1171-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 4-Hydroxy-3-(2-hydroxy-[1,1-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile

Produktbeschreibung

AMPK activator

Produkteigenschaften

• Molekulargewicht: 360.39
• Reinheit: 98% by HPLC, NMR (Conforms)
• Formulierung: Beige solid
• CAS Nummer: [844499-71-4]
• Formel: C20H12N2O3S

Anwendungsbeschreibung

• Anwendungsbeschreibung: A potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the and subunits and not the AMP binding site1. EC50=0.8 M for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 M2. Inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice2. Inhibits adipocyte differentiation3. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming4. Synergizes with AICAR5. Cell permeable.