MLN4924, CAS [[905579-51-3]]

Produktübersicht

• Artikelname: MLN4924, CAS [[905579-51-3]]
• Artikelnummer: FBM-10-1311
• Hersteller Artikelnummer: 10-1311
• Alternativnummer: FBM-10-1311-1MG, FBM-10-1311-5MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: ((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate. Alternate Names: Pevonedistat

Produktbeschreibung

Nedd8 activating enzyme inhibitor

Produkteigenschaften

• Molekulargewicht: 443.53
• Reinheit: 98% by TLC, NMR conforms
• Formulierung: White solid
• CAS Nummer: [905579-51-3]
• Formel: C21H25N5O4S

Anwendungsbeschreibung

• Anwendungsbeschreibung: MLN4924 is a potent and selective NEDD8-activating enzyme (NAE) inhibitor.1 It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. Suppresses the growth of human tumor xenografts in mice.2 Upregulates PD-L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma.3 Modulates tumor microenvironment.4 Blocks the neddylation of the DNA endonuclease CtIP, which promotes HDR in Cas9- and Cpf1-mediated gene editing. Part of the CRISPY mix for increasing precise gene editing.5 Cell permeable.