Chemical Name: 2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole
SREBP activation inhibitor
Molekulargewicht:
294.42
Reinheit:
98% by TLC, NMR (conforms)
Formulierung:
Yellow solid
CAS Nummer:
[125256-00-0]
Formel:
C18H18N2S
Anwendungsbeschreibung:
Blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Prevents increases in body weight, blood glucose and hepatic fat accumulation in obese ob/ob mice1. Inhibits high glucose-induced TGF-beta in mesangial cells2. Cell permeable.
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