SMI-4a, CAS [[438190-29-5]]

Produktübersicht

• Artikelname: SMI-4a, CAS [[438190-29-5]]
• Artikelnummer: FBM-10-1359
• Hersteller Artikelnummer: 10-1359
• Alternativnummer: FBM-10-1359-5MG,FBM-10-1359-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

PIM1 inhibitor

Produkteigenschaften

• Molekulargewicht: 273.23
• Reinheit: 98% by TLC, NMR (conforms)
• Formulierung: Tan solid
• CAS Nummer: [438190-29-5]
• Formel: C11H6F3NO2S

Anwendungsbeschreibung

• Anwendungsbeschreibung: A selective, ATP-competitive inhibitor of the Pim protein kinases (IC50 = 24 and 100 nM for Pim-1 and Pim-2 respectively). Selective over a panel of ~50 other kinases1. Induces cell cycle arrest in leukemia and prostate cancer cells2. Blocks the growth of a wide range of myeloid and lymphoid cell lines with precursor T-cell lymphoblastic leukemia/lymphoma (pre-T-LBL/T-ALL) being highly sensitive3. A useful tool for exploring the involvement of Pim in cellular signaling4. Cell permeable.