iCRT5, CAS [[18623-44-4]]

Produktübersicht

• Artikelname: iCRT5, CAS [[18623-44-4]]
• Artikelnummer: FBM-10-1371
• Hersteller Artikelnummer: 10-1371
• Alternativnummer: FBM-10-1371-5MG, FBM-10-1371-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid

Produktbeschreibung

beta-catenin inhibitor

Produkteigenschaften

• Molekulargewicht: 367.44
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [18623-44-4]
• Formel: C16H17NO5S2

Anwendungsbeschreibung

• Anwendungsbeschreibung: A selective CRT (beta-catenin-responsive transcription) inhibitor.1 IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the beta-catenin, TCF4 interaction.1 Displays poor inhibition of cell proliferation in triple-negative breast cancer cells.2 Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs.3 Modulators of Wnt signaling show great promise in animal models of several cancers.4 Cell permeable.