Chemical Name: 4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine. Alternate Names: Apafant
PAF receptor antagonist
Molekulargewicht:
455.96
Reinheit:
98% by TLC, NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[105219-56-5]
Formel:
C22H22ClN5O2S
Anwendungsbeschreibung:
Potent and selective antagonist of the platelet activating factor (PAF) receptor (Ki = 16.3 nM)1. Displays an activity profile which includes antiinflamatory, antiangiogenesis and anticancer activity2. Along with leukotriene antagonists, cooperatively provides a robust anti-inflammatory effect regulating PMNL migration and edema formation3. Displays analgesic effects in animal models of neuropathic pain4. Active in vivo.
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