Importazole, CAS [[662163-81-7]]

Produktübersicht

• Artikelname: Importazole, CAS [[662163-81-7]]
• Artikelnummer: FBM-10-1412
• Hersteller Artikelnummer: 10-1412
• Alternativnummer: FBM-10-1412-5MG,FBM-10-1412-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: IPZ

Produktbeschreibung

Blocks importin-b-mediated nuclear import

Produkteigenschaften

• Molekulargewicht: 318.43
• Reinheit: 97% by TLC, NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [662163-81-7]
• Formel: C20H22N4

Anwendungsbeschreibung

• Anwendungsbeschreibung: Specifically inhibits importin-beta-mediated nuclear import without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export1. When added to cells during mitosis it impairs the release of an importin- cargo probe and causes defects in spindle assembly. Inhibition of importin-beta function is most likely mediated by blocking its interaction with RanGTP. It is an important new tool to probe the function of the importin-/RanGTP pathway2-4. Cell permeable