680C91, CAS [[163239-22-3]]

Produktübersicht

• Artikelname: 680C91, CAS [[163239-22-3]]
• Artikelnummer: FBM-10-1443
• Hersteller Artikelnummer: 10-1443
• Alternativnummer: FBM-10-1443-5MG, FBM-10-1443-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole

Produktbeschreibung

Tryptophan 2,3-dioxygenase inhibitor

Produkteigenschaften

• Molekulargewicht: 238.27
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Light brown solid
• CAS Nummer: [163239-22-3]
• Formel: C15H11FN2

Anwendungsbeschreibung

• Anwendungsbeschreibung: A potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM)1,2. Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake. Elevates CSF tryptophan by up to 260% and CSF serotonin by 170% of basal2. TDO inhibition by 680C91 in glioma cells blocked the release of kynurenine, an endogenous tumor promoting AHR ligand4.