NSC405020, CAS [[7497-07-6]]

Produktübersicht

• Artikelname: NSC405020, CAS [[7497-07-6]]
• Artikelnummer: FBM-10-1462
• Hersteller Artikelnummer: 10-1462
• Alternativnummer: FBM-10-1462-5MG, FBM-10-1462-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3,4-Dichloro-N-(1-methylbutyl)benzamide

Produktbeschreibung

MT1-MMP inhibitor

Produkteigenschaften

• Molekulargewicht: 260.15
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [7497-07-6]
• Formel: C12H15NCl2O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14s protumorigenic activity in vivo. (IC50 > 100 µM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2. Suppresses bone erosion in a c-Fos-deficient mouse model.2 Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3