Agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at alpha4beta2 and alpha2beta2 subtypes (EC50= approximately 6 and 11 µM, respectively).1 Displays anxiolytic activity in a rat model and was 6-fold more potent than diazepam.2 Reduces distractibility in a primate model3 and may have relevance in attention deficit hyperactivity disorder4. Improves cognition in Alzheimers disease patients.5
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