XIB4035, CAS [[10023-54-8]]

Produktübersicht

• Artikelname: XIB4035, CAS [[10023-54-8]]
• Artikelnummer: FBM-10-1486
• Hersteller Artikelnummer: 10-1486
• Alternativnummer: FBM-10-1486-5MG,FBM-10-1486-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

GFRalpha1 agonist

Produkteigenschaften

• Molekulargewicht: 750.45
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Light brown solid
• CAS Nummer: [10023-54-8]
• Formel: C26H31Cl2N3 3(H3PO4)

Anwendungsbeschreibung

• Anwendungsbeschreibung: A novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor alpha-1 GFRalpha-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 µM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells1. Recent studies indicate that it enhances GFRalpha family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3 GDNF agonists may be a new class of Parkinsons disease therapeutics.4