KU-55933, CAS [[587871-26-9]]

Produktübersicht

• Artikelname: KU-55933, CAS [[587871-26-9]]
• Artikelnummer: FBM-10-1518
• Hersteller Artikelnummer: 10-1518
• Alternativnummer: FBM-10-1518-5MG, FBM-10-1518-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-(4-Morpholinyl)-6-(1-thiamthrenyl)-4H-pyran-4-one

Produktbeschreibung

ATM Kinase inhibitor

Produkteigenschaften

• Molekulargewicht: 395.50
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Tan solid
• CAS Nummer: [587871-26-9]
• Formel: C21H17NO3S2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1 Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro.2 Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3 Sensitizes radio-resistant cancer cells.4 Provides neuroprotection against H2O2-induced cell damage.5