ML323, CAS [[1572414-83-5]]

Produktübersicht

• Artikelname: ML323, CAS [[1572414-83-5]]
• Artikelnummer: FBM-10-1560
• Hersteller Artikelnummer: 10-1560
• Alternativnummer: FBM-10-1560-5MG,FBM-10-1560-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: CID 60167849, NCGC00262306

Produktbeschreibung

USP1 - UAF1 inhibitor

Produkteigenschaften

• Molekulargewicht: 384.48
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1572414-83-5]
• Formel: C23H24N6

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, IC50=76 nm in a ubiquitin-rhodamine 110 assay.1 In H1299 non-small cell lung cancer cells treatment with ML323 dose dependently and robustly increased levels of monoubiquitinated PCNA compared to untreated cells at concentrations as low as 1 M.1 It potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells.2 ML323 inhibition of upregulated USP1 in BRCA1-deficient tumor cells results in replication fork destabilization and decreased viability.3