Chemical Name: 2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
CtBP inhibitor, cdc25 phosphatase inhibitor
Molekulargewicht:
310.39
Reinheit:
98% by TLC, NMr (Conforms)
Formulierung:
Orange solid
CAS Nummer:
[93718-83-3]
Formel:
C14H14O4S2
Anwendungsbeschreibung:
A potent and selective inhibitor of Cdc25 phosphatase (Ki = 32, 96 and 40 nM for Cdc25A, B and C respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.1 Induces cell cycle arrest, phosphorylation of EGFR and activation of ERK-1 and -2.2 Inhibits carboxyl-terminal binding protein a transcriptional corepressor that suppresses multiple pro-apoptotic and epithelial genes.3 Induces eryptosis in human erythrocytes.4
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