Dabrafenib, CAS [[1195765-45-7]]

Produktübersicht

• Artikelname: Dabrafenib, CAS [[1195765-45-7]]
• Artikelnummer: FBM-10-1569
• Hersteller Artikelnummer: 10-1569
• Alternativnummer: FBM-10-1569-5MG,FBM-10-1569-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: GSK2118436

Produktbeschreibung

B-Raf mutant inhibitor

Produkteigenschaften

• Molekulargewicht: 519.56
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [1195765-45-7]
• Formel: C23H20F3N5O2S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Dabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively).1 Has been in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors. Endoplasmic reticulum stress and autophagy are induced in melanoma cells after treatment with dabrafenib and protect cells from dabrafenib toxicity.2 Induces epithelial differentiation in BRAF-mutant colorectal cancer cells.3