Chemical Name: Cyclic depsipeptide from Chromobacterium sp
Gq inhibitor
Molekulargewicht:
960.10
Reinheit:
95% by HPLC, NMR (Conforms)
Formulierung:
White or off-white lyophilize solid
CAS Nummer:
[568580-02-9]
Formel:
C46H69N7O15
Anwendungsbeschreibung:
YM-254890 is a novel Galphaq/11 inhibitor,1 U46619-induced platelet aggregation is inhibited but phorbol ester- or ionophore-induced aggregation is not2 (IC50 = 0.1-0.2 µM)1. It blocks Pasteurella multocida toxin-mediated activation of Galphaq.3 A highly useful new tool for studying Galphaq/11-coupled receptor signaling and resulting cellular events.4
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