AS-8351, CAS [[796-42-9]]

Produktübersicht

• Artikelname: AS-8351, CAS [[796-42-9]]
• Artikelnummer: FBM-10-1597
• Hersteller Artikelnummer: 10-1597
• Alternativnummer: FBM-10-1597-5MG,FBM-10-1597-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: NSC-51355

Produktbeschreibung

KDM5B histone demethylase inhibitor

Produkteigenschaften

• Molekulargewicht: 291.30
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [796-42-9]
• Formel: C17H13N3O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts1. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.1