Chemical Name: 5,6-Dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]thieno[2,3-d]pyrimidin-4-amine benzenesulfonate hydrochloride
Fatty acid synthase inhibitor
Molekulargewicht:
374.93
Reinheit:
98% by TLC, NMR (Conforms)
Formulierung:
Pale yellow solid
CAS Nummer:
[929978-58-5]
Formel:
C19H22N4S HCl
Anwendungsbeschreibung:
Potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding.1 IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose incorporation into total lipids in HepG2 cells. IC50=5.84 µM in an isolated enzyme assay. Displays potent antitumor activity in the MMTV-Neu HER2+ breast cancer model.1 Reduces HIV-1 virion production by 90% (EC50=213 nM).2
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