JIB-04, CAS [[199596-05-9]]

Produktübersicht

• Artikelname: JIB-04, CAS [[199596-05-9]]
• Artikelnummer: FBM-10-1618
• Hersteller Artikelnummer: 10-1618
• Alternativnummer: FBM-10-1618-5MG, FBM-10-1618-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (E)-5-Chloro-2-(2-(phenyl(pyridine-2-yl)methylene)hydrazinyl)pyridine

Produktbeschreibung

pan-JUMONJI histone demethylase inhibitor

Produkteigenschaften

• Molekulargewicht: 308.76
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [199596-05-9]
• Formel: C17H13ClN4

Anwendungsbeschreibung

• Anwendungsbeschreibung: A novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. Reduces tumor burden and prolongs life in a mouse model.1 Suppresses translation initiation and enhances mTOR inhibitor sensitivity.2 Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.3