Itraconazole, CAS [[84625-61-6]]

Produktübersicht

• Artikelname: Itraconazole, CAS [[84625-61-6]]
• Artikelnummer: FBM-10-2033
• Hersteller Artikelnummer: 10-2033
• Alternativnummer: FBM-10-2033-50MG,FBM-10-2033-250MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Oriconazole, R51211

Produktbeschreibung

Autophagy inducer / inhibits glioblastoma growth

Produkteigenschaften

• Molekulargewicht: 705.63
• Reinheit: 98% by HPLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [84625-61-6]
• Formel: C35H36Cl2N8O4

Anwendungsbeschreibung

• Anwendungsbeschreibung: Itraconazole inhibits the conversion of lanosterol to ergosterol via inhibition of the 14-alpha demethylase, a cytochrome P-450 enzyme1. Clinically useful antifungal agent. It inhibits the proliferation of glioblastoma cells in vitro and in vivo by inducing autophagic progression via inhibiting the trafficking of cholesterol from late endosomes and lysosomes to the plasma membrane2. Inhibits the hedgehog pathway by binding to Smoothened (SMO) via a mechanism distinct from that of cyclopamine3. Inhibits angiogenesis via inhibiting the binding of VEGF to VEGFR24.