DRB, CAS [[53-85-0]]

Produktübersicht

• Artikelname: DRB, CAS [[53-85-0]]
• Artikelnummer: FBM-10-2047
• Hersteller Artikelnummer: 10-2047
• Alternativnummer: FBM-10-2047-10MG, FBM-10-2047-50MG, FBM-10-2047-10MM/1MLDMSO
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole. Alternate Names: 5,6-Dichlorobenzimidazole riboside, NSC 401575

Produktbeschreibung

Transcription inhibitor, CK2 inhibitor

Produkteigenschaften

• Molekulargewicht: 319.14
• Reinheit: 98% by HPLC NMR (conforms)
• Formulierung: White solid
• CAS Nummer: [53-85-0]
• Formel: C12H12Cl2N2O4

Anwendungsbeschreibung

• Anwendungsbeschreibung: A classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 µM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for processive transcription elongation by RNA polymerase II.1,2 Also inhibits casein kinase II, IC50=4-10 µM. 3 Suppresses the SIRT1/CK2alpha pathway and enhances the radiosensitivity of human cancer cells.4 Kinase-independent activities of Cdk9 such as glucocorticoid receptor modulation are not inhibited by DRB.5