Ionomycin, CAS [[56092-81-0]]

Produktübersicht

• Artikelname: Ionomycin, CAS [[56092-81-0]]
• Artikelnummer: FBM-10-2079
• Hersteller Artikelnummer: 10-2079
• Alternativnummer: FBM-10-2079-1MG,FBM-10-2079-5MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

Calcium ionophore

Produkteigenschaften

• Molekulargewicht: 709.01
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Yellow oil or waxy solid
• CAS Nummer: [56092-81-0]
• Formel: C41H72O9

Anwendungsbeschreibung

• Anwendungsbeschreibung: Highly selective nonfluorescent calcium (Ca2+) ionophore.1 Induces a rapid rise in cytosolic Ca2+ in human neutrophils which is due to both release from cytosolic Ca2+ stores as well as Ca2+ influx.2 It activates (2 µM) and primes (20-200 nM) neutrophil NADPH oxidase2. Down regulates beta-catenin/Tcf signaling in a colon cancer cell line via suppressing the binding of Tcf to its specific DNA-binding site.3 In rat hepatoma cells, sub-lethal ionomycin activates the stress response by activating SAPK/JNK and HSF/HSE interaction leading to upregulation of HSP70 biosynthesis.4