Chemical Name: Isolated from marine dionflagellates. Alternate Names: NSC 677083
Protein phosphatase PP2A inhibitor
Molekulargewicht:
805.00
Reinheit:
98% by TLC, NMR (Conforms)
Formulierung:
Off-white solid
CAS Nummer:
[78111-17-8]
Formel:
C44H68O13
Anwendungsbeschreibung:
A naturally occurring polyether marine toxin. Potent and selective inhibitor of protein phosphatases inhibiting PP2A completely at 1 nM and PP1 at higher concentrations, while PP2C is not inhibited. It is an extremely useful tool for studying cellular protein phosphorylation2. Induces apoptosis in a variety of cell types3. Activates atypical protein kinase isotypes and induces insulin-like effects in adipocytes4. Caution: SKIN IRRITANT, TUMOR PROMOTOR. Avoid contact.
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