Radicicol, CAS [[12772-57-5]]

Produktübersicht

• Artikelname: Radicicol, CAS [[12772-57-5]]
• Artikelnummer: FBM-10-2102
• Hersteller Artikelnummer: 10-2102
• Alternativnummer: FBM-10-2102-1MG, FBM-10-2102-5MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione. Alternate Names: Monorden

Produktbeschreibung

HSP90 inhibitor

Produkteigenschaften

• Molekulargewicht: 364.78
• Reinheit: 99% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [12772-57-5]
• Formel: C18H17ClO6

Anwendungsbeschreibung

• Anwendungsbeschreibung: Radicicol inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket.1 In cells Hsp90 client proteins such as Raf kinase2, HIF-1alpha3 and estrogen receptor4 are destabilized and proteolytically degraded. Inhibits expression of COX-2 without affecting COX-1 expression in LPS-stimulated macrophages (IC50=27 nM).5 Inhibits angiogenesis.6