Withaferin A, CAS [[5119-48-2]]

Produktübersicht

• Artikelname: Withaferin A, CAS [[5119-48-2]]
• Artikelnummer: FBM-10-2114
• Hersteller Artikelnummer: 10-2114
• Alternativnummer: FBM-10-2114-1MG, FBM-10-2114-5MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (4beta, 5beta, 6beta, 22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid delta-lactone. Alternate Names: NSC-101088

Produktbeschreibung

NFkappaB and angiogenesis inhibitor

Produkteigenschaften

• Molekulargewicht: 470.60
• Reinheit: 99% by HPLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [5119-48-2]
• Formel: C28H38O6

Anwendungsbeschreibung

• Anwendungsbeschreibung: Displays potent antiangiogenesis activity inhibiting endothelial cell sprouting in vitro (IC50 = 12 nM) and in vivo.1 Potently inhibits NF-kappaB activation by preventing TNFalpha-induced activation of IKKbeta.2 Covalently binds to the intermediate filament protein, vimentin3 inducing its disassembly and serine 56 phosphorylation4. Inhibits reactive gliosis and blocks TNFalpha-mediated neuronal apoptosis in in vivo models.5