Axitinib, CAS [[319460-85-0]]

Produktübersicht

• Artikelname: Axitinib, CAS [[319460-85-0]]
• Artikelnummer: FBM-10-2118
• Hersteller Artikelnummer: 10-2118
• Alternativnummer: FBM-10-2118-10MG, FBM-10-2118-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-Methyl-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide

Produktbeschreibung

VEGFR kinase inhibitor

Produkteigenschaften

• Molekulargewicht: 386.47
• Reinheit: 99% by HPLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [319460-85-0]
• Formel: C22H18N4OS

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent inhibitor of VEGFR-2, -3, and -1, IC50 = 0.2, 0.1-0.3, and 1.2 nM respectively1 displaying minimal activity against a panel of ~100 protein kinases. Inhibits angiogenesis and vascular permeability.2 Also inhibits BCR-ABL1 (T315I) with high potency, Ki = 149 pM for autophosphorylated ABL1 (T315I).3 Inhibits proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Clinically useful anticancer agent.4