Chemical Name: 1-(5-Isoquinolinesulfonyl)homopiperazine HCl. Alternate Names: HA-1077
ROCK inhibitor
Molekulargewicht:
327.84
Reinheit:
98% by TLC, NMR (conforms)
Formulierung:
White solid
CAS Nummer:
[105628-07-7]
Formel:
C14H17N3O2S HCl
Anwendungsbeschreibung:
Rho-associated kinase inhibitor (IC50 = 1.9 µM and 10.7 µM for Rho-associated kinase II and Rho-associated kinase respectively)1. Inhibits other kinases including cyclic nucleotide-dependent protein kinases.1 Reduces tryptamine-evoked vasopressor responses.2 attenuates bleomycin-induced pulmonary fibrosis in a mouse model.3 Clinically useful vasodilator.
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