Gemcitabine HCl, CAS [[122111-03-9]]

Produktübersicht

• Artikelname: Gemcitabine HCl, CAS [[122111-03-9]]
• Artikelnummer: FBM-10-2140
• Hersteller Artikelnummer: 10-2140
• Alternativnummer: FBM-10-2140-10MG,FBM-10-2140-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: dFdC

Produktbeschreibung

DNA polymerase inhibitor

Produkteigenschaften

• Molekulargewicht: 299.66
• Reinheit: 98%
• Formulierung: White solid
• CAS Nummer: [122111-03-9]
• Formel: C9H11F2N3O4HCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: Gemcitabine is a clinically useful anticancer agent.1 It exerts its cytotoxic effects via the metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCTP is an inhibitor of DNA polymerase and is also incorporated in DNA strands resulting in termination of chain elongation and apoptosis. dFdCDP is an inhibitor of ribonucleotide reductase which results in depletion of deoxyribonucleotides needed for DNA synthesis. Gemcitabine metabolites have also been reported to inhibit cytidine triphosphate synthetase (CTP synthetase)2 and deoxycytidylate deaminase (dCMP deaminase)3. Topoisomerase 1 has also been shown to be a target for gemcitabine.4