GW-2580, CAS [[870483-87-7]]

Produktübersicht

• Artikelname: GW-2580, CAS [[870483-87-7]]
• Artikelnummer: FBM-10-2143
• Hersteller Artikelnummer: 10-2143
• Alternativnummer: FBM-10-2143-5MG, FBM-10-2143-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine

Produktbeschreibung

cFMS kinase inhibitor

Produkteigenschaften

• Molekulargewicht: 366.32
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [870483-87-7]
• Formel: C20H22N4O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases1. Completely inhibits CSF-1 induced growth of mouse M-NFS-60 myeloid cells and human monocytes (at 1 µM)1. Completely inhibits bone degradation in human osteoclasts, rat calvaria and fetal long bone1. Inhibits LPS-induced TNF production in mice. Abrogates infiltration of macrophages into synovial joints of arthritic mice2. Active in vivo.