Irinotecan HCl, CAS [[136572-09-3]]

Produktübersicht

• Artikelname: Irinotecan HCl, CAS [[136572-09-3]]
• Artikelnummer: FBM-10-2146
• Hersteller Artikelnummer: 10-2146
• Alternativnummer: FBM-10-2146-50MG, FBM-10-2146-250MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3,4:6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4-bipiperidine]-1-carboxylate hydrochloride

Produktbeschreibung

Topoisomerase I inhibitor

Produkteigenschaften

• Molekulargewicht: 586.69 36.46 54.05
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [136572-09-3]
• Formel: C33H38N4O6 HCl 3H20

Anwendungsbeschreibung

• Anwendungsbeschreibung: Irinotecan is a semi-synthetic derivative of camptothecin that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3