Sorafenib (base), CAS [[284461-73-0]]
Artikelnummer:
FBM-10-2174
| Artikelname: |
Sorafenib (base), CAS [[284461-73-0]] |
| Artikelnummer: |
FBM-10-2174 |
| Hersteller Artikelnummer: |
10-2174 |
| Alternativnummer: |
FBM-10-2174-10MG, FBM-10-2174-50MG |
| Hersteller: |
Focus Biomolecules |
| Kategorie: |
Biochemikalien |
| Alternative Synonym: |
Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide. Alternate Names: BAY 43-9006 |
| Raf-1 inhibitor (and other kinases) |
| Molekulargewicht: |
464.83 |
| Reinheit: |
99% by TLC, NMR (Conforms) |
| Formulierung: |
Off-white solid |
| CAS Nummer: |
[284461-73-0] |
| Formel: |
C21H16ClF3N4O3 |
| Anwendungsbeschreibung: |
Initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM), VEGFR-2 (IC50 = 90 nM), VEGFR-3 (IC50 = 20 nM), PDGFR-beta (IC50 = 57 nM), Flt3 (IC50 = 58 nM), c-KIT (IC50 = 68 nM), FGFR-1 (IC50 = 580 nM)1. Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms2. Inhibits activation of MAPK pathway and ERK phosphorylation3. Induces caspase-independent apoptosis in melanoma cells4. Clinically useful anticancer agent. |
