ß-Lapachone, CAS [[4707-32-8]]

Produktübersicht

• Artikelname: ß-Lapachone, CAS [[4707-32-8]]
• Artikelnummer: FBM-10-2386
• Hersteller Artikelnummer: 10-2386
• Alternativnummer: FBM-10-2386-5MG, FBM-10-2386-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione. Alternate Names: NSC-26326

Produktbeschreibung

Topoisomerase I inhibitor

Produkteigenschaften

• Molekulargewicht: 242.27
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Orange solid
• CAS Nummer: [4707-32-8]
• Formel: C15H14O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: A naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae). A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action.1 Induces apoptosis in a number of cancer cell lines.2 In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of -lapachone leads to futile cycling between quinone and hydroquinone forms3 resulting in the production of reactive oxygen species4. Suppresses radiation-induced activation of NFB.5