Veliparib 2HCl, CAS [[912445-05-7]]

Produktübersicht

• Artikelname: Veliparib 2HCl, CAS [[912445-05-7]]
• Artikelnummer: FBM-10-2419
• Hersteller Artikelnummer: 10-2419
• Alternativnummer: FBM-10-2419-5MG, FBM-10-2419-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide dihydrochloride. Alternate Names: ABT-888

Produktbeschreibung

PARP 1&2 inhibitor

Produkteigenschaften

• Molekulargewicht: 317.22
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [912445-05-7]
• Formel: C13H16N4O2HCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent and selective PARP-inhibitor with Ki values of 5.2 nM and 2.9 nM for PARP-1 and PARP-2, respectively.1 Restores sensitivity to DNA alkylator/methylator temozolomide in glioma cells and xenografts2, and enhances radiotherapy sensitivity in endometrial carcinoma cells3. Also improves sensitivity to DNA replication inhibitor cisplatin in human oral carcinoma cells.4