SC-560, CAS [[188817-13-2]]

Produktübersicht

• Artikelname: SC-560, CAS [[188817-13-2]]
• Artikelnummer: FBM-10-2531
• Hersteller Artikelnummer: 10-2531
• Alternativnummer: FBM-10-2531-5MG, FBM-10-2531-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole

Produktbeschreibung

Selective COX-1 inhibitor

Produkteigenschaften

• Molekulargewicht: 352.74
• Reinheit: >98% by TLC NMR (Conforms)
• Formulierung: Brown solid
• CAS Nummer: [188817-13-2]
• Formel: C17H12ClF3N2O

Anwendungsbeschreibung

• Anwendungsbeschreibung: SC-560 is a highly selective (700-fold selective over COX-2) and potent (IC50 = 9 nM) inhibitor of cyclooxygenase-1(COX-1).1 SC-560 inhibited TNFa-induced PGE2 synthesis in neurons and, PGE2 and thromboxane A2 synthesis in human monocytes and platelets (IC50s = 1.8 nM and 2.5 nM respectively) indicating non-selective COX inhibition. SC-560 was able to inhibit PGE2 synthesis in COX-1-deficient neurons indicating a COX-1 independent mechanism. This unselective COX inhibition was only observed in whole cells - it remained COX-1 specific in cell lysates.2