Chemical Name: Isolated from Microcystis aeruginosa (a freshwater cyanobacteria)
Protein phosphatase PP1 and PP2A inhibitor
Molekulargewicht:
995.17
Reinheit:
95% by HPLC NMR (Conforms)
Formulierung:
Off-white lyophilized solid (vial appear empty)
CAS Nummer:
[101043-37-2]
Formel:
C49H74N10O12
Anwendungsbeschreibung:
A novel freshwater cyanotoxin.1 Tumor promoter. Potent and selective inhibitor of protein phosphatase 2A (PP2A), IC50=0.04 nM. PP1, IC50=1.7 nM and PP2B are less sensitive and PP2C is not inhibited (up to 4 µM).2 Considered to be cell-impermeable with the exception of hepatocytes which take it up via an organic anion transporter.3
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