SB-225002, CAS [[182498-32-4]]

Produktübersicht

• Artikelname: SB-225002, CAS [[182498-32-4]]
• Artikelnummer: FBM-10-2850
• Hersteller Artikelnummer: 10-2850
• Alternativnummer: FBM-10-2850-5MG, FBM-10-2850-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-(2-Bromophenyl)-N-(2-hydroxy-4-nitrophenyl)urea

Produktbeschreibung

CXCR2 antagonist

Produkteigenschaften

• Molekulargewicht: 352.14
• Reinheit: 98% by HPLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [182498-32-4]
• Formel: C13H10BrN3O4

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent and selective CXCR2 receptor antagonist (IC50 = 22 nM). Displays >150-fold selectivity over CXCR1 receptors.1 Induces apoptosis in both wild-type and p53-deficient ovarian cancer cells (OVCA) via p53 activation and by inducing mitotic catastrophe.2 Blocks IL-8-mediated cellular effects such as oxidative stress-induced cellular senescence3 and neutrophil chemotaxis1. Inhibits HIV replication in lymphocytes and macrophages.4 Inhibits endothelial activation and leukocyte recruitment to cerebral microvessels during neuroinflammation.5