Kifunensine, CAS [[109944-15-2]]

Produktübersicht

• Artikelname: Kifunensine, CAS [[109944-15-2]]
• Artikelnummer: FBM-10-2860
• Hersteller Artikelnummer: 10-2860
• Alternativnummer: FBM-10-2860-1MG,FBM-10-2860-5MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione. Alternate Names: FR-900494

Produktbeschreibung

Mannosidase inhibitor

Produkteigenschaften

• Molekulargewicht: 232.19
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [109944-15-2]
• Formel: C8H12N2O6

Anwendungsbeschreibung

• Anwendungsbeschreibung: Historically isolated from Kitasatosporia kifunensee.1 Inhibitor of class I alpha-mannosidases which inhibit glycoprotein processing. Inhibits human endoplasmic reticulum alpha-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.2 Inhibition of endoplasmic reticulum alpha-mannosidase I activity rescues the human alpha-sarcoglycan R77C mutation suggesting a new pharmacological approach for limb girdle muscular dystrophy type 2D patients carrying mutations that impair alpha-sarcoglycan trafficking.3 Improves maturation of misfolded proteins.4