Chemical Name: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide. Alternate Names: BTP2
CRAC channel blocker
Molekulargewicht:
421.32
Reinheit:
98% by TLC NMR (Conforms)
Formulierung:
Off-white solid
CAS Nummer:
[223499-30-7]
Formel:
C15H9F6N5OS
Anwendungsbeschreibung:
YM-58483 is a CRAC (calcium release-activated calcium) channel blocker1, a prototypic store-operated calcium channel2. Inhibits antigen-induced histamine release via modulation of mast cell responses.3 Displays potent analgesic actions in various pain models in mice and is orally active.4 Inhibits T cell-mediated immune responses in vivo.5
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