Chemical Name: (5S,6R)-Methyl 5,6,7-trihydroxyheptanoate
LXA agonist, antiinflammatory
Molekulargewicht:
192.21
Reinheit:
99% by TLC NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[78606-80-1]
Formel:
C8H16O5
Anwendungsbeschreibung:
A novel truncated analog of lipoxin A4 which retains anti-inflammatory activity.1 Inhibits LTB4-induced leukocyte chemotaxis, IC50=5 nM).1 Attenuates hemorrhagic shock-induced acute lung injury in a rat model.2 Displays hepatoprotective effects in acetaminophen-induced liver injury in mice.3 Limits inflammatory damage in the cerebral cortex and helps maintain blood brain barrier integrity in a rat model of ischemic stroke.4 Attenuates renal ischemia/reperfusion injury via activation of p38 MAPK/PPARalpha/HO-1 pathway.5
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