Koningic acid, CAS [[74310-84-2]]

Produktübersicht

• Artikelname: Koningic acid, CAS [[74310-84-2]]
• Artikelnummer: FBM-10-3326
• Hersteller Artikelnummer: 10-3326
• Alternativnummer: FBM-10-3326-200UG,FBM-10-3326-1MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (2S,5aS,6R,9aS)-1,5a,6,7,8,9a-Hexahydro-6-(1-methylethyl)-1-oxo-spiro[2-benzoxepin-9(3H)2-oxirane]-4-carboxylic acid. Alternate Names: Heptelidic acid, BRN5091359, Avocettin

Produktbeschreibung

Glyceraldehyde-3-phosphate dehydrogenase inhibitor

Produkteigenschaften

• Molekulargewicht: 280.32
• Reinheit: 95% by HPLC, NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [74310-84-2]
• Formel: C15H20O5

Anwendungsbeschreibung

• Anwendungsbeschreibung: Koningic acid (KA) is a potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).1 Inhibition is irreversible and proceeds via nucleophilic attack of an active site cysteine on the epoxide moiety2, Ki = 1.1 µM for rabbit muscle GAPDH3. KA can selectively kill high-glycolytic cancer cells via glucose dependent ATP depletion.4 Has been used in a predictive model for selective targeting of the Warburg effect, the most prominent hallmark of cancer cell metabolism.5

Bilder

10-3326