CPI-613, CAS [[95809-78-2]]

Produktübersicht

• Artikelname: CPI-613, CAS [[95809-78-2]]
• Artikelnummer: FBM-10-3519
• Hersteller Artikelnummer: 10-3519
• Alternativnummer: FBM-10-3519-5MG, FBM-10-3519-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 6,8-bis(benzylthio-octanoic acid),. Alternate Names: Devimistat

Produktbeschreibung

KGDH and PDH inhibitor

Produkteigenschaften

• Molekulargewicht: 388.59
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [95809-78-2]
• Formel: C22H28O2S2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Lipoic acid analog which potently disrupts mitochondrial metabolism with selectivity for tumor cells in vitro and shows strong antitumor activity in vivo.1 Inhibits alpha-ketoglutarate dehydrogenase (KGDH) by a redox mechanisms selectively in tumor cells.2 Inhibits pyruvate dehydrogenase (PDH) as a mechanistically distinct, non-redox, effect.1,2 A novel anticancer agent with a mitochondria-targeted mode of action with non-genotoxic propertie.3. Has been used (along with PS48) to induce a Warburg-like metabolic state in fibroblasts.4 Combination treatment of CPI-613 and chloroquine inhibits the progression of clear cell sarcoma in a mouse model.5