Verrucarin A, CAS [[3148-09-2]]

Produktübersicht

• Artikelname: Verrucarin A, CAS [[3148-09-2]]
• Artikelnummer: FBM-10-3564
• Hersteller Artikelnummer: 10-3564
• Alternativnummer: FBM-10-3564-1MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Alternate Names: Muconomycin-A, 379-Y, Glutinosin-I, Myrothecin-I, NSC-126728

Produktbeschreibung

Steroid receptor coactivator-3 inhibitor

Produkteigenschaften

• Molekulargewicht: 502.56
• Reinheit: >98% by HPLC, NMR (conforms)
• Formulierung: Off-white solid
• CAS Nummer: [3148-09-2]
• Formel: C27H34O9

Anwendungsbeschreibung

• Anwendungsbeschreibung: A macrocyclic trichothecene mycotoxin from Myrothecium sp. It is a potent and selective inhibitor of the steroid receptor coactivator-3 and selectively down-regulates its expression.1 It is cytotoxic to multiple types of cancer cells at low nM concentrations (IC50=4.9 nM for HepG2 cells) but not toward normal liver cells.1,2 It enhances TNFalpha-induced3 and TRAIL-induced apoptosis4. It reduces phosphorylation of IREalpha and inhibits tunicamycin-induced ER stress in FaO rat liver cells.5