Neratinib, CAS [[698387-09-6]]

Produktübersicht

• Artikelname: Neratinib, CAS [[698387-09-6]]
• Artikelnummer: FBM-10-3658
• Hersteller Artikelnummer: 10-3658
• Alternativnummer: FBM-10-3658-20MG, FBM-10-3658-100MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide. Alternate Names: HKI-272

Produktbeschreibung

Dual EGFR and HER2 inhibitor

Produkteigenschaften

• Molekulargewicht: 557.05
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [698387-09-6]
• Formel: C30H29ClN6O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: Neratinib is a potent, irreversible inhibitor of HER2/ErbB2 receptor tyrosine kinase and EGFR kinase (IC50s= 59 nM and 92 nM, respectively). It suppresses receptor autophosphorylation and proliferation, blocks cell-cycle progression and inhibits HER2 signaling in of EGFR-dependent cancer cells and tumor xenograft models.1 Neratinib inhibits proliferation of gefitinib-resistant non-small cell lung cancer cells expressing mutant EGFR.2 Synergizes with dasatinib in HER2-positive cancer cells and xenografts.3 Its been shown to also inhibit MST1 (IC50 = 37.7 nM).4