Chemical Name: N-[-4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
Glucose uptake inhibitor
Molekulargewicht:
279.64
Reinheit:
98% by TLC, NMR (Conforms)
Formulierung:
Off-white solid
CAS Nummer:
[392721-37-8]
Formel:
C11H9ClF3NO2
Anwendungsbeschreibung:
A novel inhibitor of glucose uptake which acts via inhibition of the glucose transporter GluT1 and GluT4 (IC50=68 M).1 Inhibition of glucose uptake is cell type specific2 and is a promising approach to new cancer therapeutics3. Rescues cardiac progenitor cell dysfunction and mitochondrial fission induced by high glucose4. Sensitizes cells to FAS-induced cell death.5,6
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