DJ001, CAS [[2161305-12-8]]

Produktübersicht

• Artikelname: DJ001, CAS [[2161305-12-8]]
• Artikelnummer: FBM-10-3800
• Hersteller Artikelnummer: 10-3800
• Alternativnummer: FBM-10-3800-5MG,FBM-10-3800-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

PTPsigma inhibitor / Promotes stem cell regeneration

Produkteigenschaften

• Molekulargewicht: 268.27
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [2161305-12-8]
• Formel: C15H12N2O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: DJ001 (2161306-12-8) is a potent and specific inhibitor of receptor type protein tyrosine phosphatase-sigma (PTP) IC50=1.54 M and >10 M for 20 other phosphatases.1 Promotes hematopoietic stem cell regeneration in vivo. In mice treated with 5-fluorouricil or irradiated, DJ001 promoted HSC regeneration accelerated hematologic recovery and improved survival. The mode of inhibition of PTP is via non-competitive allosteric binding. Suppression of radiation-induced HSC apoptosis occurs via activation of Rho GTPase, Rac1 and induction of BCL-XL. Treatment of irradiated human HSCs with DJ001 promotes the regeneration of human HSCs capable of multilineage in vivo repopulation.1