ZJ43, CAS [[723331-20-2]]

Produktübersicht

• Artikelname: ZJ43, CAS [[723331-20-2]]
• Artikelnummer: FBM-10-3904
• Hersteller Artikelnummer: 10-3904
• Alternativnummer: FBM-10-3904-5MG,FBM-10-3904-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

Potent inhibitor glutamate carboxypeptidases II and III

Produkteigenschaften

• Molekulargewicht: 304.30
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [723331-20-2]
• Formel: C12H20N2O7

Anwendungsbeschreibung

• Anwendungsbeschreibung: ZJ43 is potent inhibitor of glutamate carboxypeptidases II (Ki = 0.8 nM) and III (Ki = 23 nM).1 It blocks MDA-MB-468 cell growth with an IC50 = 3.4 nM without effecting normal cells.1 It potently (IC50 = 2.4 nM) inhibited the ability of glutamate carboxypeptidase II to hydrolyze the neurotransmitter N-acetylaspartylglutamate (NAAG) resulting in an increase in synaptic levels of group II mGluRs. Peripherally administered ZJ43 increased the activation of mGluR3 by NAAG released from peripheral sensory neurites resulting in analgesia.2,3 ZJ43 has also shown efficacy in other inflammatory pain models.4,5