Chemical Name: 4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide. Alternate Names: MDV3100, ASP-9785
Non-steroidal antiandrogen
Molekulargewicht:
464.44
Reinheit:
99% by HPLC NMT (Conforms)
Formulierung:
White or off-white solid
CAS Nummer:
[915087-33-1]
Formel:
C21H16F4N4O2S
Anwendungsbeschreibung:
Clinically useful non-steroidal antiandrogen (IC50 = 36 nM) for the treatment of castration-resistant prostate cancer.1,2 It impairs binding of the androgen receptor to DNA, the recruitment of co-activators, and reduces the efficiency of nuclear translocation.
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