CIB-3b, CAS [[124811-87-6]]

Produktübersicht

• Artikelname: CIB-3b, CAS [[124811-87-6]]
• Artikelnummer: FBM-10-3923
• Hersteller Artikelnummer: 10-3923
• Alternativnummer: FBM-10-3923-5MG,FBM-10-3923-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

Inhibitor of microRNA biogenesis

Produkteigenschaften

• Molekulargewicht: 261.28
• Reinheit: >98% by HPLC , NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [124811-87-6]
• Formel: C14H15NO4

Anwendungsbeschreibung

• Anwendungsbeschreibung: CIB-3b inhibits microRNA (miRNA) biogenesis via binding (KD = 10.42 nM) to transactivation response (TAR) RNA-binding protein 2 (TRBP), disrupting the TRBP-Dicer interaction, a critical element in pre-miRNA processing. It inhibited mi-R21 (EC50 = 1.38 µM) expression, a potent inducer of cellular EMT progression. CIB-3b inhibited hepatocarcinogenesis by blocking EMT in a mouse orthotopic transplantation model (SK-HEP-1 cells).