E7820, CAS [[289483-69-8]]

Produktübersicht

• Artikelname: E7820, CAS [[289483-69-8]]
• Artikelnummer: FBM-10-3935
• Hersteller Artikelnummer: 10-3935
• Alternativnummer: FBM-10-3935-5MG, FBM-10-3935-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-(3-Cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzenesulfonamide

Produktbeschreibung

RBM39 molecular glue

Produkteigenschaften

• Molekulargewicht: 336.37
• Reinheit: 98% by HPLC , NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [289483-69-8]
• Formel: C17H12N4O2S

Anwendungsbeschreibung

• Anwendungsbeschreibung: E7820 is an angiogenesis inhibitor that suppresses expression of integrins alpha2, alpha3, alpha5, and ß1.1 Broad-spectrum antitumor and antiangiogenic effects are mainly mediated via integrin alpha2 suppression.2 E7820 has been identified as a molecular glue that induces proteasomal degradation of the U2AF-related splicing factor CAPERalpha (RBM39) via CRL4DCAF15 mediated ubiquitination in human cancer cell lines.3,4 E7820 has also been shown to induce degradation of the aryl hydrocarbon receptor nuclear translator (ARNT), a protein essential in maintaining cellular homeostasis in response to environmental stress.5